Page 38 - MDA MIDEC 2024 Programme Book

DAY 3 - CONFERENCE SPEAKER

Mechanism of Action of Zinc Hydroxyapatite
Zn-HAp mimics the natural composition of dental tissues, promoting
remineralization and repair. Its biomimetic properties allow it to integrate
seamlessly with the tooth structure. The primary mechanisms by which
Zn-HAp benefits dental health include:

1. Remineralization: Zn-HAp provides calcium and phosphate ions
necessary for the remineralization of demineralized enamel and dentin.
This process restores the mineral content and structural integrity of
the tooth, reversing early stages of dental caries (tooth decay).

2. Tubule Occlusion: Dentin hypersensitivity (DH) is a common dental
problem characterized by sharp pain in response to stimuli such as
thermal, evaporative, tactile, osmotic, or chemical triggers. Traditional
treatments often include fluoride, but recent studies have shown that
Zn-HAp can be more effective. Zn-HAP blocks the dentinal tubules,
preventing stimuli from reaching the nerves in the dental pulp.
Clinical trials have demonstrated that Zn-HAP-containing oral care
products significantly reduce DH more effectively than fluoride and
other desensitizing agents

3. Antibacterial Properties: The incorporation of zinc imparts antibacterial
properties to the hydroxyapatite. Zinc ions can inhibit the growth of
cariogenic bacteria, such as Streptococcus mutans, thereby reducing
the risk of dental caries.

Clinical Applications
1. Prevention of Dental Caries: Zn-HAP is effective in preventing dental
caries by enhancing the remineralization process. This is particularly
beneficial for individuals with high caries risk or those who prefer
fluoride-free alternatives.

2. Treatment of Dentin Hypersensitivity: Zn-HAP has been shown to
provide significant relief from dentin hypersensitivity. It is incorporated
into various dental care products, including toothpaste and mouth
rinses.

3. Orthodontics and Periodontology: In orthodontics, Zn-HAP is used to
manage white spot lesions commonly seen in patients undergoing
braces treatment. In periodontology, it serves as a graft material due to
its osteogenic properties, aiding in bone regeneration around implants
and periodontal defects.

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