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ORAL PRESENTATION ABSTRACTS

P017 Name of Presenter: Alia Binti Mohammed Ghazali, Department of Oral & Maxillofacial
Sciences, Faculty of Dentistry, Universiti Malaya
Title of Presentation: Utilizing Platelet-Rich Fibrin for Oroantral Fistula Closure: Insights
from a Case Series in a University Teaching Hospital Setting

Abstract
A.M. Ghazali 1,*, WC Ngeow 1, M.K. Hassan 1, CC Tan 1
1Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya

Introduction: Oroantral communication (OAC) refers to an abnormal connection or opening between the
oral cavity and the maxillary sinus that can arise from various dental procedures, primarily the extraction
of maxillary posterior teeth. If an OAC persists and becomes epithelialized, it may develop into an oroantral
fistula (OAF), in which it warrants a more complicated treatment. Untreated OAC can lead to complications
like sinus infections, chronic sinusitis, and difficulties in eating and speaking. It often requires prompt and
effective treatment to close the communication and prevent further issues. While smaller communications
may resolve spontaneously, larger defects necessitate surgical intervention to close the fistula and prevent
further complications.
One emerging treatment option for the closure of oroantral communications is the use of platelet-rich
fibrin (PRF). It is a second-generation platelet concentrate that has demonstrated remarkable properties
in promoting tissue healing and regeneration. In the context of OACs, the application of platelet-rich fibrin
has been explored as a minimally invasive and effective means of sealing the communication between the
oral cavity and maxillary sinus.
Case Report: This case series report presents three clinical cases where patients were referred for OACs
complicated post extraction of maxillary molars. PRF from patient’s blood was used as a clot and a
membrane for the closure of OACs. The patients were monitored postoperatively, and successful closure of
the defects was observed without any inflammatory reactions or sinus pathoses.
Discussion: PRF demonstrated its potential in guiding cell migration, stimulating tissue regeneration, and
providing a natural fibrin matrix for healing. The simplicity, cost-effectiveness, and positive outcomes of
using PRF for OAC closure highlight its promising role in maxillofacial surgery. In summary, PRF offers
several advantages, particularly in terms of enhanced healing, reduced patient morbidity, and improved
blood supply, making it a favorable option for the closure of smaller OACs.

Key words: platelet-rich fibrin, oroantral communication

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